High content screening, or high content analysis, is an advanced analytical process that identifies particles that alter the phenotype of a cell in a desired manner. The key benefit being the short amount of time the process takes. Advancements in the relevant technology have produced tools and techniques like high content screening that allow laboratories of variable size to take on a higher rate of experiments. Parallel acquisition of data on different cell properties has now been streamlined to the point where the required investment of both money and man-hours has been greatly reduced.
Modern advancements in the tools used in cellular biology, robotics and automated high-resolution microscopes are at the crux of the current, highly advanced state of high content analysis. In the process, cells are isolated and incubated with chemicals or RNAi reagents that flag compounds that alter cellular phenotypes. Modern techniques allow us to measure the changes in the proteins manufactured by cells at a faster rate. This ultimately allows a much higher number of parallel processes to be run.
Through high content screening, living cells can be used in biological research to compare and contrast the inner workings of diseased and healthy cells. Further applications include the ability to more precisely test drug candidates in order to better optimize and refine them. Of course the benefit of high content analysis to pharmaceutical companies has long been obvious, and its versatility in practice means that it will continue to be implemented across a wide array of fields.
Most importantly, utilizing high content analysis allows for multiple, simultaneous analyses to be run at once, allowing you and your team to track a larger number of biochemical and morphological parameters. As such, a greater number of experiments can be performed and analyzed simultaneously. Because high content screening has become more affordable in recent years, a variety of fields, including agro-chemical, clinical diagnostic, and consumer-focused production have diversified its applications through inventive investing and development. The required equipment has also been greatly reduced in size, minimizing the space needed and allowing labs of variable size to benefit. This affordability, along with the far-advanced technology and the relatively small space the equipment now occupies, has created the opportunity for a variety of fields to take advantage of high content analysis. As more and more fields capitalize on the ever-advancing technology it will be interesting to see what further developments we'll witness.
SLAS is a worldwide community of individual scientists and researchers provide you High Content Screening technology. High Content Analysis allows for multiple, simultaneous analyses to be run at once, allowing you and your team to track a larger number of biochemical and morphological parameters. Rate this ArticleThe Benefits of Working With High Content ScreeningRating: 5.0/5 (1 vote cast)M J Smith has published 12 articles. Article submitted on October 31, 2013. Word count: 403India has been prominent worldwide for its highly elevating and enriching education, since the times of Nalanda University, which was the first university offering university system of education to the whole world.
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